Set up your Account the right way

First and foremost – add an avatar, something personable – a picture of yourself is always easiest. Fill in your bio honestly, describe what you do, don’t use capitals. Just think of this as the first tweet to introduce you to the twitter world.
Try something like this

I am an avid Social Media and internet lover, I enjoy all things media – music, movies, art. I currently reside in Mytown, California!

Don’t tweet trending topics just to be part of the list…

You have seen them before clicking on a trending topic – the top 5 or so tweets include all the trending topics. Don’t be one of those people… if you want to tweet about a trending topic – well tweet something interesting about one of them. Here’s what mashable.com has to say about “trending topic spam” - link.

Don’t Follow Spammers

If you don’t want to be tagged as a spammer – why relate yourself to them. Don’t just follow anybody, only follow users that are worth following (their tweets are on a topic that interests you).

Don’t Automate your tweets

When tweeting – make it personable, don’t be a robot. Twitter is about communicating with other normal people, we don’t want to see auto-generated or program-generated messages.

Auto DM’s

Plain and Simple. Don’t sign up for those stupid apps that auto DM (Direct Message) someone that follows you. DM Spam is a very annoying twitter spam technique – many users don’t even look in their DM inbox anymore due to auto-generated DMs. Of course, a spammer can only auto-DM you if you are both following each other, so only follow other users that you are interested in hearing about.

Follow Spam

Follow spam is the act of following mass numbers of people, not because you’re actually interested in their tweets, but simply to gain attention, get views of your profile (and possibly clicks on URLs therein), or (ideally) to get followed back. Many people who are seeking to get attention in this way have even created programs to do the following on their behalf, which enable them to follow thousands of people at the blink of any eye. – Twitter | Reference Link

Content is KING

Twitter is a great application, and a useful tool – there is a sea of great quality content out there – links to tech news, design showcases, breaking news and etc… Next time you tweet, ask yourself “Is this something useful – will my followers be interested in this”

Do you have any suggestions on how not to be seen as a Twitter spammer?

Don’t become a twitter spammer is a post from The Dustpan - Discussing Twitter Spam